Insulin requirements may be increased by substances w/ hyperglycaemic activity eg, glucocorticoids, thyroid hormones, growth hormone, danazol, β
2-sympathomimetics (eg, ritodrine, salbutamol, terbutaline), thiazides. Insulin requirements may be reduced by drugs w/ hypoglycaemic activity eg, oral hypoglycaemics, salicylates (eg, ASA), certain antidepressants (MAOIs), certain ACEIs (captopril, enalapril), angiotensin II receptor blockers, non-selective β-blocking agents & alcohol. Somatostatin analogues (octreotide, lanreotide) may both decrease or increase insulin dose requirements.